AKRİLAMİDE MARUZ KALAN SIÇANLARIN KALP DOKUSU ÜZERİNDE SELENYUMUN KORUYUCU ROLÜ

Objective
 Acrylamide (ACR) is a harmful organic reactive compound
 widely used in different industrial fields. Sele-
 nium (SEL) trace element that takes part some
 chemical and enzymatic reactions both animals
 human organisms can cause some disorders
 many systems such as the cardiovascular
 system case of deficiency. The aim this study is
 to investigate whether SEL has protective effect on
 cardiac tissue experimentally induced ACR toxicity
 rats.
 Material Method
 A total 28 rats were randomly equally divided
 into four groups: Control, SEL, ACR, + ACR. At
 end study, markers creatine
 kinase MB (CKMB), lactate dehydrogenase (LDH)
 ischemia-modified albumin (IMA) from blood
 samples measured. Oxidative stress markers
 oxidant status (TOS), antioxidant
 (TAS) oxidative index (OSI) heart
 analyzed. In addition, inducible nitric oxide
 synthase iNOS activities determined sections using immunohistochemical methods.
 Results
 group showed significant decrease
 TOS, OSI, CKMB, LDH, IMA levels significant
 increase TAS level compared group.
 histopathological evaluation
 heart sections; Disorganization cardiac
 muscle fibers, increased connective between
 fibers irregular eosinophilia muscle
 detected group. decrease in
 findings was observed SEL
 treated groups iNOS
 immunoreactivities; moderate marking observed
 sections, while poor was
 Conclusion
 We caused damage through various metabolic pathways and
 these damages reversed given
 SEL.